PD Dr. André Fedier - Stv. Forschungsleiter; Experimentelle Gynäkologie

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Current research projects

Project leader	Project title
Fedier Imesch	Endometriosis and epigenetics - Blocking the proliferative, migratory, invasive, angiogenic, and estrogen-responsive properties of endometriotic cells in vitro by HDAC-inhibitors
	GPER, a GTP-coupled estrogen receptor: Modulation of its activity by agonists and antagonists and effects on proliferation and intracellular kinase signaling in endometriotic cells

Completed research projects

Project leader	Project title
Fedier	Modulation of DNA mismatch repair-mediated drug sensitivity by an HSP90 inhibitor
	PI3K/Akt signaling inhibition and effects on platinum drug sensitivity in DNA mismatch repair-deficient and -proficient tumor cells
	Claspin and signal transduction initiated by DNA mismatch repair
	Histone deacetylase inhibitors - Role in drug resistance acquisition
	Activation of apoptosis by cytoplasmic delivery of “exogenous” cytochrome c to cancer cells by transporter peptides or by liposomes
	3’-end processing (mRNA polyadenylation) inhibition and effects on proliferation and survival of endometriotic cells
	MLH1-deficiency in tumor cells and effects on sensitivity to the poly(A) polymerase inhibitor Cordycepin
	DNA mismatch repair defect and sensitivity of tumor cells to liposomal formulations of platinum drugs
Fink	The effect of an anthracycline-based chemotherapy on DNA mismatch repair-deficient tumor cells in breast cancer patients
	Drug hypersensitivity of p53-deficient cells following the genetic disruption of DNA repair genes
	Increased chemosensitivity of p53-deficient tumor cells due to loss of the DNA mismatch repair gene PMS2
	Drug resistance due to loss of DNA mismatch repair (MMR)
	MMR-deficient tumor cells retain sensitivity to photodynamic therapy