Csomor
Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Affektive Erkrankungen und Allgemeinpsychiatrie Zürich Ost, Klinik für » Prof. Dr. Daniel Hell (emeritiert) » Csomor
Completed research project
| Title / Titel | Impact of neurochemical manipulation on sensory gating in healthy subjects with low gating levels: validation of the translational model | ||||
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| Abstract (PDF, 14 KB) | |||||
| Summary / Zusammenfassung | The concomitant assessment of PPI and P50 suppression in healthy subjects with low baseline gating levels, in combination with neuropsychological testing, may provide a valid translational model to elucidate the neural basis of PPI and P50 suppression deficits and its relation to cognition. In this proof of concept study, further psychoactive compounds, including antipsychotics, are being tested in order to validate and extend our current model of sensory and sensorimotor gating in healthy human volunteers exhibiting low baseline gating performance. This validation study aims to elucidate the applicability of our translational model to serve as a useful tool for the assessment of the efficacy of novel pharmacotreatment strategies for patients suffering from schizophrenia spectrum disorders. | ||||
| Keywords / Suchbegriffe | prepulse inhibition, P50 suppression, cognition, translational medicine | ||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Private Sector (e.g. Industry) |
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| Duration of Project / Projektdauer | Oct 2007 to Aug 2009 |