Böker Northoff
Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Affektive Erkrankungen und Allgemeinpsychiatrie Zürich Ost, Klinik für » Prof. Dr. Daniel Hell (emeritiert) » Böker Northoff
Completed research project
| Title / Titel | Glutamatergic Modulation of Retrieval of Episodic Memory: A Combined Neuropsychological and fMRI-Study | ||||||||
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| Abstract (PDF, 14 KB) | |||||||||
| Original title / Originaltitel | Hirnaktivierungsmuster beim Lernen und Wiedererkennen von episodischen Gedächtnisinhalten bei neurochemischer Stimulation mit Ketamin: Eine kombinierte neuropsychologische und fMRI-Studie | ||||||||
| Summary / Zusammenfassung | Memory of personally experienced events (i.e. episodic memory) may be closely related to construction of a model of the own self as well as to higher- order cognitive functions normally ascribed to fronto- hippocampal function. It has been hypothesized that both generation of the self and retrieval of episodic memory may be closely related to fronto-hippocampal function which may be modulated by Glutamatergic neurotransmission via NMDA-receptors. However relationship between generation of the self, retrieval of episodic memory, fronto-hippocampal function, and NMDA-receptors and their alteration in schizophrenic patients with self- related episodic disturbances remain unclear. Therefore we investigated constructions of the self and retrieval of episodic memory combining neuropsychological measures of the self and episodic memory with functional imaging techniques for spatiotemporal activation patterns including functional Magnetic Resonance Imaging (fMRI). Further elucidation of cortical basis of generation of self and episodic retrieval was achieved by employing neurochemical challenges of the NMDA-antagonist Ketamine during both neuropsychological and functional imaging. In a first step the connection between fronto-hippocampal activation and retrieval of episodic memory was investigated in healthy controls. In a second step the fronto-hippocampal dysfunctions during the retrieval of episodic memory will be investigated in schizophrenic patients using a combined neuropsychological and functional imaging approach. Results: Retrieval of episodic memory induced signal increases in posterior and anterior cingulate which were significantly attenuated by Ketamine. Moreover, attenuated signal increases in posterior cingulate correlated significantly with both number of mistakes in retrieval and positive i.e. psychosis-like symptoms. Conclusion: The study demonstrates for the first time a relationship between NMDA-receptors, posterior cingulate and positive i.e. psychosis-like symptoms in humans. |
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| Publications / Publikationen | Northoff G., Richter A., Bermpohl F., Grimm S., Martin E., Marcar V.L., Wahl C., Hell D., Böker H. (2004) NMDA-Hypofunction in the Posterior Cingulate as a Model for Schizophrenia: An Exploratory Ketamine Administration Study in fMRI. Schizophrenia Research 72 (2-3): 235-248Böker H, Northoff G, Lenz C, Schmeling C v, Eppel A, Härtling F, Will H, Hell D (2000) Die Rekonstruktion der Sprachlosigkeit: Untersuchungen subjektiven Erlebens ehemals katatoner PatientInnen mittels modifizierter Landfield-Kategorien. Psychiat. Prax. 27: 389-396Northoff G, Steinke R, Nagel D, Czerwenka C Grosser O, Danos P, Gnez A, Krause R, Böker H, Otto HJ, Bogerts B (2000) Right lower prefronto-parietal cortical dysfunction in akinetic catatonia: a combined study of neuropsychology and regional cerebral blood flow. Psychol. Med. 30: 1-14 | ||||||||
| Keywords / Suchbegriffe | episodic memory, self models, neuropsychology, fMRI, fronto-hippocampal function, glutamatergic modulation, schizophrenia | ||||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Universität Zürich (position pursuing an academic career), Forschungskredit der Universität Zürich, Private Sector (e.g. Industry) Stifzung für wissenschaftliche Forschung an der Universität Zürich |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Oct 1999 to Dec 2004 |