Schuepbach
Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Affektive Erkrankungen und Allgemeinpsychiatrie Zürich Ost, Klinik für » Prof. Dr. Daniel Hell (emeritiert) » Schuepbach
Completed research project
| Title / Titel | Cerebral hemodynamics during Wisconsin Card Sorting Test: neuropsychological and neurophysiological characterization | ||||||
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| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | The Wisconsin Card Sorting Test (WCST) is a well-known paradigm of abstraction and cognitive flexibility. We have shown that WCST elicits a distinct pattern of cerebral blood flow velocity (CBFV) changes as measured by Transcranial Doppler sonography (TCD). Response latency (RL) increased during search of a new category (i.e. extradimensional shift) as compared to maintaining a rule (i.e. intradimensional shift). During repeated administration of this task, reduced response latencies over time were noted and interpreted as practice effect. Concomitantly, a slight decrease of CBFV was observed. Intra- and extradimensional shifts represent different cognitive processes. The aim of this project is to examine the association between different behavioural responses and cerebral hemodynamics. Further, we hypothesize that time has a differential effect on response latency during intra- and extradimensional shift across repeated WCST administrations. Emphasis is on the association of neurophysiological and neuropsychological variables. | ||||||
| Publications / Publikationen | Schuepbach D, Merlo MCG, Dierks T, Brenner HD (2002) Cerebral Hemodynamic Response Induced by the Tower of Hanoi Puzzle and the Wisconsin Card Sorting Test. Neuropsychologia 40, 39-53Schuepbach D, Goenner F, Staikov I, Mattle H, Hell D, Brenner HD (2002) Temporal modulation of cerebral hemodynamics under prefrontal challenge in schizophrenia: a transcranial Doppler sonography study. Psychiatry Research: NeuroImaging 115, 155-170 | ||||||
| Keywords / Suchbegriffe | Neurophysiology, neuropsychology, prefrontal cortex, Transcranial Doppler sonography, Wisconsin Card Sorting Test | ||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Foundation Hartmann Müller-Stiftung für Medizinische Forschung |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | 2002 to 2003 |