Stassen
Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Affektive Erkrankungen und Allgemeinpsychiatrie Zürich Ost, Klinik für » Prof. Dr. Daniel Hell (emeritiert) » Stassen
Completed research project
| Title / Titel | Oligogenic Approaches to the Predisposition of Asthma in Ethnically Diverse Populations: Analysis of a Multinational Sample | ||||||||
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| Abstract (PDF, 14 KB) | |||||||||
| Summary / Zusammenfassung | The genetic analysis of complex disorders influenced by multiple genes as well as multiple non-genetic factors is still an unresolved methodological issue. Using a novel multilocus genotype-to-phenotype research strategy, we are able to quantify between-population, within-population, and within-family genetic similarities. Based on family data from three European ethnicities (Germany, UK, Potugal), our project aims at elucidating ethnicity-independent as well as ethnicity-specific susceptibility to asthma and atopy. The question of ethnicity-independent susceptibility is addressed by treating the German families —ascertained from a population with intermediate prevalences of atopy and asthma— as “training” samples, while the British families —ascertained from a population with high prevalences of atopy and asthma— serve as independent “test” samples, along with the Portuguese families who stemmed from a region with low prevalences of atopy and asthma. Our results will pave the way for systematic investigations into complex disorders, in particular psychiatric disorders, and will allow us to address the question of the extent to which genetic risk factors and their interactions constitute multigenic inheritance across populations and constitute universal targets for treatment. Weitere Informationen |
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| Publications / Publikationen | Stassen HH, Scharfetter C: Oligogenic approaches to the predisposition of asthma in ethnically diverse populations. Genetic Analysis Workshop 12: Analysis of genetic and environmental factors in common diseases. Genetic Epidemiology 2001; 21 Suppl 1: 284-289Scharfetter C, Kurz T, Hoffmann K, Deichmann KA, Stassen HH: Oligogenic approaches to the predisposition of atopy in ethnically diverse populations. Analysis of a multinational sample. Neurol Psychiat Brain Res 2004; 11: 27-36Kurz T, Altmueller J, Strauch K, Rueschendorf F, Heinzmann A, Moffatt MF, Cookson W, Inacio F, Nuernberg P, Stassen HH, Deichmann KA: A genome-wide screen on the genetics of atopy in a multiethnic European population reveals a major atopy locus on chromosome 3q21.3. Allergy, Eur J of Allergy and Clinical Immunology 2005; 60(2): 192-199Berger M, Stassen HH, Köhler K, Krane V, Mönks D, Wanner C, Hoffmann K, Hoffmann MM, Zimmer M, Bickeböller H, Lindner TH: Hidden population substructures in an apparently homogeneous population bias association studies. Eur J Hum Genetics 2006; 14: 236-244Weitere Informationen | ||||||||
| Keywords / Suchbegriffe | asthma, atopy, complex disorders, molecular genetics, genetic diversity, population admixture | ||||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Foundation |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Jun 2004 to Jun 2008 |