Vollenweider
Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Affektive Erkrankungen und Allgemeinpsychiatrie Zürich Ost, Klinik für » Prof. Dr. Daniel Hell (emeritiert) » Vollenweider
Completed research project
| Title / Titel | Detectability of prepulse-elicited reaction in prepulse inhibition of the acoustic startle reflex in humans | ||||
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| Abstract (PDF, 14 KB) | |||||
| Summary / Zusammenfassung | Prepulse inhibition (PPI) refers to the attenuation of the reflexive startle reaction towards an intense pulse stimulus when its presentation is shortly preceded by a weak prepulse stimulus. PPI deficiency has been noted in a number of psychiatric conditions including schizophrenia and schizotypal personality disorder. The possibility that the prepulse stimulus typically employed in the studies of prepulse inhibition (PPI) can produce observable response has been questioned recently. Conflicting reports range from observations of prepulse-elicited startle reaction to a complete lack of detectable prepulse-elicited reactions in healthy volunteers. This controversy is subjected to critical examination in the present study. | ||||
| Publications / Publikationen | Poster, Zurich Neuroscience Centre Meeting 2004, ZurichCsomor PA, Vollenweider FX, Feldon J, Yee BK. 2005. On the feasibility to detect and to quantify prepulse-elicited reaction in prepulse inhibition of the acoustic startle reflex in humans. Behav Brain Res 162(2):256-263. | ||||
| Keywords / Suchbegriffe | attention,prepulse inhibition,schizophrenia,sensorimotor gating,prepulse detection,startle | ||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Foundation Olga Mayenfisch Foundation Zurich |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Aug 2004 to Apr 2005 |