Schuepbach
Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Affektive Erkrankungen und Allgemeinpsychiatrie Zürich Ost, Klinik für » Prof. Dr. Daniel Hell (emeritiert) » Schuepbach
Completed research project
| Title / Titel | A prospective controlled study on the predictive role of clinical symptoms and functional transcranial Doppler sonography on the development of vocational function in schizophrenia | ||||||
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| Abstract (PDF, 14 KB) | |||||||
| Summary / Zusammenfassung | Schizophrenia is a severe mental disorder with long-term disability. Negative symptoms and cognitive deficits such as executive functions play a crucial role in long-lasting vocational deficits, and the underlying pathophysiological mechanisms of those symptoms have been extensively investigated with neuroimaging studies. Despite these facts, to the best of our knowledge no studies have examined the associations between pathophysiological variables such as cerebral blood flow (CBF) under challenge of executive functions and work performance. The primary objective of this prospective controlled study is to examine the association between CBF during executive challenge as assessed by functional Transcranial Doppler sonography (fTCD) and vocational functioning in chronic schizophrenia and in a control group of patients suffering from depression. We hypothesize that fTCD can be used to predict work performance in schizophrenia on a routine basis. | ||||||
| Publications / Publikationen | Schuepbach D., Hill S.K., Sanders R.D., Hell D., Keshavan M.S., Sweeney J.A. Early, Treatment-Induced Improvement of Negative Symptoms Predicts Cognitive Functioning in Treatment-Naïve First-Episode Schizophrenia: a 2-Year Follow-Up. Schizophrenia Bulletin, 30 (4):837-848, 2004Frauenfelder B.A., Schuepbach D., Baumgartner R.W., Hell D. Specific alterations of cerebral hemodynamics during a planning task: a transcranial Doppler sonography study. Neuroimage 22:1223-1230, 2004.Sanders R.D., Schuepbach D., Goldstein G., Haas G.L., Sweeney J.A., Keshavan M.S. Relationships between cognitive and neurologic performance in neuroleptic-naive psychosis. Journal of Neuropsychiatry and Clinical Neurosciences 16 (4):480-487, 2004. |
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| Keywords / Suchbegriffe | depression, cbf, fTCD, neurological signs, schizophrenia, vocational functioning | ||||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Others |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Apr 2005 to Mar 2008 |