Schwab
Fakultäten » Medizinische Fakultät » Hirnforschung, Institut für » Prof. Dr. Martin E. Schwab » Schwab
Current research project
| Title / Titel | Clinical trials with anti-Nogo-A antibodies | ||||
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| Abstract (PDF, 14 KB) | |||||
| Summary / Zusammenfassung | In collaboration with Novartis, an anti-human Nogo-A antibody was generated and extensively tested toxicologically. A Phase I clinical trial (coordinated by Novartis, Basel) is currently being finalized in a European Network of Spinal Cord Injury Centres (EM-SCI, coordinated by Prof. Armin Curt, University Paraplegic Center Balgrist Zurich), using this anti Nogo-A antibody in acutely injured paraplegic patients. For Phase II elaborate functional readouts are being developed to gain detailed information on any sensory or motor improvements occurring. Weitere Informationen |
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| Publications / Publikationen | Weitere Informationen | ||||
| Keywords / Suchbegriffe | clinical trial, injuries of the central nervous system, regeneration, plasticity, Nogo-A antibodies | ||||
| Project leadership and contacts / Projektleitung und Kontakte |
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| Funding source(s) / Unterstützt durch |
Forschungskredit der Universität Zürich, SNF (Personen- und Projektförderung), SNF (Programm NFS/NCCR), EU, Foundation, Private Sector (e.g. Industry) |
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| In collaboration with / In Zusammenarbeit mit |
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| Duration of Project / Projektdauer | Jun 2006 to Jul 2014 |